Depline 75mg Tablet is a tricyclic antidepressant. Different doses of this medicine help in treating and preventing different problems such as depression, neuropathic pain, and migraine.

Depline 75mg Tablet is used to treat various features of depression

Uses of Depline Tablet

Benefits of Depline Tablet

In Treatment of Depression

Depline 75mg Tablet works by affecting the balance of certain chemicals (such as serotonin) in the brain. It helps improve mood and feelings of well-being, relieve anxiety and tension, helps you sleep better, and increase your energy level. Depline 75mg Tablet is readily absorbed and starts action within approximately 6 hours of taking it orally (by mouth). It is an effective antidepressant but may cause drowsiness. You need to take it regularly as it is prescribed for it to be most effective and should not stop taking it suddenly.

In Neuropathic pain

Depline 75mg Tablet helps in relieving neuropathic pain caused by nerve damage in certain conditions. These may include painful diabetic neuropathy, post-herpetic neuralgia, or spinal cord disease. It works by affecting chemicals in the brain called neurotransmitters. By relieving pain, it helps improve your quality of life.

In Treatment of Migraine

Depline 75mg Tablet helps prevent migraines by changing the way that your nerves receive pain signals. By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

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Side effects of Depline Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Depline

Constipation
Dryness in mouth
Orthostatic hypotension (sudden lowering of blood pressure on standing)
Weight gain
Aggressive behavior
Nasal congestion (stuffy nose)
Sleepiness
Dizziness
Headache
Decreased libido
Nausea
Fatigue
Confusion
Tremors
Speech disorder
Palpitations
Taste change
Paresthesia (tingling or pricking sensation)
Abnormality of voluntary movements
Loss of accommodation
Atrioventricular block
Micturition disorders
Erectile dysfunction
Abnormal ECG
Decreased sodium level in blood

How to use Depline Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depline 75mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Depline Tablet works

Depline 75mg Tablet contains Amitriptyline, a tricyclic antidepressant. It has anticholinergic and sedative properties. It prevents the reuptake, and hence the inactivation of neurotransmitters called noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain (pain from damaged nerves).

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Depline 75mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Depline 75mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Depline 75mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Driving

UNSAFE

Depline 75mg Tablet may cause side effects which could affect your ability to drive.
Depline 75mg Tablet may impair your alertness which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Depline 75mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Depline 75mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Depline 75mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Depline 75mg Tablet may be needed. Please consult your doctor.
Use of Depline 75mg Tablet is not recommended in patients with severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

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Quick tips

It may take 4 to 6 weeks for Depline 75mg Tablet to start working. Keep taking it as prescribed.
It may cause sleepiness. Take it at bedtime and do not drive or do anything requiring concentration until you know how it affects you.
Avoid consuming alcohol when taking Depline 75mg Tablet as it may cause excessive sleepiness.
Monitor your weight during the treatment as this medicine can cause weight gain and increased appetite.
It may cause sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.

Fact Box

Chemical Class

Dibenzocycloheptenes Derivative

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Tricyclic antidepressants

Patient concerns

Most of the times when I get excited or have orgasm I feel pain in my testis and around it .

Dr. Pranay Gandhi

Sexology

hi PATIENT neuropathic pain mostly. take tablet emanzen d 1 bd

Sir Plz suggest me effective pain killer with minimum side effects for back pain and arthritis, which can be taken on regular basis as and when required.

Dr. Vikas Sharma

Neurology

dpeneds on the type of pain - muscular or neuropathic; show tro nearby neuro

FAQs

What other lifestyle changes should I make to get maximum benefit of Depline 75mg Tablet?

Antidepressants, including Depline 75mg Tablet, are just one of several approaches to treat depression. Certain lifestyle changes can help you get maximum benefit of Depline 75mg Tablet and help you recover fast. Keeping active and eating a healthy diet can make a significant difference to how quickly you recover from depression. Think positively and try to discuss your thoughts with others to reduce stress. Practice yoga or take up a hobby. Ensure that you have a sound sleep to calm your mind. Stay away from smoking or alcohol consumption as these will only worsen your depression. Take your medicines as prescribed even if you start feeling better.

Is there anything I need to be careful about while on therapy with Depline 75mg Tablet?

Depline 75mg Tablet may cause drowsiness and dizziness, especially in the beginning of the treatment. So, avoid driving or using machinery until you know how the medicine affects you. Also, it is not advisable to drink alcohol during treatment with this medicine as it might increase sleepiness.

Can the use of Depline 75mg Tablet affect my sex life?

Yes, Depline 75mg Tablet can affect sex life in both men and women. It may cause decreased sexual desire or you may experience discomfort during intercourse. Men may experience inability to develop or maintain an erection during sexual activity and may be unable to have an orgasm. If you notice these symptoms, do not stop taking the medicine but consult your doctor.

I have been taking Depline 75mg Tablet for depression since a week and recently I have been wanting to harm myself. What should I do? Is it because of the medicine?

You should immediately consult your doctor or go to the hospital. Your suicidal tendencies may have increased because of your disease or the medicine. Generally, Depline 75mg Tablet takes about 2 weeks to show its effect but may take longer. Therefore, when you start taking Depline 75mg Tablet, you may have thoughts about killing or harming yourself. This is more common in people who previously had suicidal tendencies or are young adults (less than 25 years old). However, the effect of medicine is different for every individual.

Can Depline 75mg Tablet cause urinary problems?

Yes, Depline 75mg Tablet can cause urinary problems. It is more commonly seen in elderly patients who are more than 65 years old. The patient may face difficulty in passing urine which can further lead to a urinary tract infection. Consult your doctor immediately if you develop these symptoms.

If my pain is not relieved, can I take more than the recommended dose?

No, you should use Depline 75mg Tablet strictly as prescribed by the doctor. If the dose exceeds, you may develop drowsiness, confusion, difficulty in speech, dry mouth, tiredness, difficulty in walking, fever, difficulty in breathing, blue discoloration of the skin and decreased heartbeat. Your pain may not be relieved because Depline 75mg Tablet takes about 2 weeks to show its effect, but it may take longer in some cases. The duration of treatment can differ from individual to individual. Consult your doctor if your symptoms are not relieved.

Does Depline 75mg Tablet cause any effect on pregnancy or the newborn?

Do not take Depline 75mg Tablet during pregnancy unless recommended by the doctor. If you take this medicine during the last trimester of the pregnancy, the newborn may develop symptoms such as irritability, rigidity, irregular body movements, irregular breathing, poor drinking, loud crying, difficulty in urinating and constipation.

I have been prescribed Depline 75mg Tablet for pain. When will I start feeling better?

You may start feeling better after 2 weeks of starting Depline 75mg Tablet. However, it may take 4-6 weeks to see the full benefits of the medicine.

Can I stop taking Depline 75mg Tablet when my pain is relieved?

No, do not stop taking Depline 75mg Tablet even if the pain is relieved. You should use Depline 75mg Tablet as advised by the doctor. Stopping the medicine suddenly may cause unpleasant symptoms like headache, feeling unwell, sleeplessness and irritability. Consult your doctor for the duration of the treatment since the dose of Depline 75mg Tablet needs to be reduced gradually.

How long does Depline 75mg Tablet take to work?

You may see an improvement in your symptoms after a couple of weeks, although it usually takes between 4 and 6 weeks before you feel the benefits. Do not stop taking Depline 75mg Tablet after 1 or 2 weeks just because you feel it is not helping your symptoms. Give the medicine at least 6 weeks to work.

How will Depline 75mg Tablet make me feel?

Antidepressants like Depline 75mg Tablet help to gradually lift your mood. You may notice that you sleep better and are less anxious. You may worry less about little things that used to bother you. Depline 75mg Tablet will not make you feel excessively or unusually happy. It will help you feel like yourself again.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Stahl SM, editor. Amitriptyline. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 25-30.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 58-59.
Amitriptyline. Princeton: Sandoz Inc; 2014. [Accessed on 19 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Amitriptyline. [Updated 2018 Oct 31]. [Accessed 19 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 19 Mar. 2019] (online) Available from:

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