Matnib 400mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors. It is used in the treatment of blood cancer (chronic myeloid leukaemia and Acute lymphocytic leukemia) and gastrointestinal stromal tumor.

Matnib 400mg Tablet should be taken with food, but better to have it same time every day to get the most benefit. You should continue to take it as long as your doctor advises for it. The duration of treatment varies according to your need and response to treatment. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue, and abdominal pain. Let your doctor know if you experience unexpected rapid weight gain. Your doctor may advise for regular monitoring of blood cells and liver function while you are taking this medicine. Do not drive or do anything requiring mental focus if you experience dizziness and blurry vision.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Matnib Tablet

Blood cancer (Chronic myeloid leukaemia)
Blood cancer (Acute lymphocytic leukemia)
Gastrointestinal stromal tumour

Benefits of Matnib Tablet

In Blood cancer (Chronic myeloid leukaemia)

Blood cancer, also called leukemia, is a cancer of the blood-forming tissues, that decreases the body's ability to fight infection. Matnib 400mg Tablet kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.

In Blood cancer (Acute lymphocytic leukemia)

In Gastrointestinal stromal tumour

A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs most commonly in the stomach or small intestine. The tumors develop into the specialized cells called interstitial cells of Cajal (ICCs). Matnib 400mg Tablet helps to kill the cancer cells and also stops their further growth and spread. Follow your doctor’s instructions carefully to get the most benefit.

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Side effects of Matnib Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Matnib

Edema (swelling)
Nausea
Vomiting
Muscle cramp
Musculoskeletal (bone, muscle or joint) pain
Diarrhea
Rash
Fatigue
Abdominal pain

How to use Matnib Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Matnib 400mg Tablet is to be taken with food.

How Matnib Tablet works

Matnib 400mg Tablet is an anti-cancer medication. A protein enzyme, bcr-abl tyrosine kinase, responsible for the growth of abnormal proliferation of cancer cells. This medicine inhibits the proliferation and induces apoptosis (planned cell death) in bcr-abl positive cells (cancer cells). This is how it works to stop or slow the spread of cancer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Matnib 400mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Matnib 400mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Matnib 400mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Lactating women should not breastfeed while using this drug and one month after stopping it.

Driving

UNSAFE

Matnib 400mg Tablet may cause side effects which could affect your ability to drive.

Kidney

CAUTION

Matnib 400mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Matnib 400mg Tablet may be needed. Please consult your doctor.

Liver

CAUTION

Matnib 400mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Matnib 400mg Tablet may be needed. Please consult your doctor.

What if you forget to take Matnib Tablet?

If you miss a dose of Matnib 400mg Tablet, skip it and continue with your normal schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Matnib 400mg Tablet

₹252.0/Tablet

Imatib 400 Tablet

Cipla Ltd

₹153.51/tablet

39% cheaper

Veenat 400 Tablet

Natco Pharma Ltd

₹202.7/tablet

20% cheaper

Imat 400 Tablet

Zydus Healthcare Limited

₹184.91/tablet

27% cheaper

Imatinib 400 Tablet

₹250/tablet

1% cheaper

Glivec 400mg Tablet

Novartis India Ltd

₹238/tablet

6% cheaper

View all substitutes

Quick tips

Always take it with food and a full glass of water to prevent nausea.
It may cause dizziness or blurred vision. Do not drive or do anything requiring concentration until you know how it affects you.
Water retention and swelling are very common side effects of Matnib 400mg Tablet. Notify your doctor if you have unexpected rapid weight gain.
Do not change the dose or discontinue use without consulting your doctor.
Notify your doctor about all the medications you are taking, including over the counter medicines and dietary supplements.
Your doctor may get regular blood tests done to monitor your liver function and the number of blood cells in your blood.

Fact Box

Chemical Class

Benzanilides Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Patient concerns

Can blood cancer patients 1st stage do sex with normal girl Sir a blood cancer patients do sex with normal girl can any problem or cause doing with girl or side effect give suggestions Thanks

Dr. Vijay Sharnangat

Medical Oncology and Hematology

Wait till blood cancer gets cured.

Mh mother have blood cancer .recently she got her first induction chemotherapy.in CBC test Immature myeloid cells 18 percent what are indicate.is it serious .is it shown presence of cancer in blood old tell me

Dr. Ila Jain Khandelwal

Pathology

Dear Mam Greetings from 1mg, The reports shows low hemoglobin and platelet count which can be due to chemotherapy.

FAQs

Can Matnib 400mg Tablet be taken with food?

Yes, the best way to take it is with a glass of water and food. This prevents irritation in the food pipe and stomach. If you cannot swallow it, put the tablets in a glass of water or apple juice (approximately 50 ml for a 100 mg tablet and 200 ml for a 400 mg tablet). Stir it with a spoon to make it uniform and drink it immediately.

Is it safe to drive while taking Matnib 400mg Tablet?

Matnib 400mg Tablet may cause dizziness, lightheadedness or drowsiness in some people. Make sure you know how you react to it before you drive a car or operate machinery.

What precautions need to be followed while taking Matnib 400mg Tablet?

While taking Matnib 400mg Tablet, make sure you follow all the instructions given by your doctor, carefully and keep all appointments. You will need regular follow-up to ensure that the treatment is working. Regular blood tests, weight checks, and urine tests may be required to find out any side effects before it becomes serious. Make sure you use a method of contraception to prevent pregnancy during treatment with Matnib 400mg Tablet. Tell your doctor immediately if you become pregnant while you are taking this medicine. If you are about to start taking any new medicine, remind your doctor that you are taking Matnib 400mg Tablet.

Ever since I started using Matnib 400mg Tablet, I have noticed that I develop rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?

This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness or severe sunburn. When you are outdoors, wear protective clothing and use a sunscreen with an SPF of 15 or higher. If you feel a burning sensation on your skin, tell your doctor.

The doctor has advised me not to take any medicine on my own while taking Matnib 400mg Tablet. Should I consult my doctor even if I need to take paracetamol for my fever?

Yes, there are a number of medicines which interfere with Matnib 400mg Tablet, including paracetamol. Therefore you should not self medicate while taking Matnib 400mg Tablet. Other medicines which interfere with Matnib 400mg Tablet include cyclosporin, dexamethasone (a steroid), warfarin, antiviral medicines which treat AIDS and some medicines which treat bacterial infections, high cholesterol, high blood pressure, heart problems, and mental disorders and depression. Consult your doctor before taking any medicine, and inform him that you are on Matnib 400mg Tablet therapy.

What precautions need to be followed while taking Matnib 400mg Tablet?

Can I expect that if I take Matnib 400mg Tablet regularly and as advised by the doctor for CML, I will be cured?

Matnib 400mg Tablet has proved effective in many cases of CML. It is also noticed that the chances of survival increase after taking this medicine. The doctor who is treating CML can tell you better. The doctor will analyze your current state, blood test results, response to treatment, any other medical illness which you may be having, etc. and tell you.

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Related lab tests

Bcr-Abl Gene Translocation (Qualitative)

Bcr-Abl Gene Translocation (Quantitative)

Complete Blood Count

Peripheral Smear Examination

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1732-34.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 953.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 692-94.
Imatinib mesylate. East Hanover, New Jersey: Novartis Pharmaceuticals Corporation; 2001 [revised Jan 2012]. [Accessed 23 Jan. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Imatinib. [Updated 2018 Oct 31]. [Accessed 18 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.