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Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate is a combination of four medicines: Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate1, Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate2, Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate3, and Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate4. Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate1 is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate2 is a plant derivative which activates certain receptors to cause prolonged desensitization of the local pain nerves. Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate3 is a non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Gabapentin + Capsaicin Based Rubefacients + Ketoprofen + Methyl Salicylate4 is used as topical analgesic (pain reliever). It works by first cooling the skin then warming it up. This cooling and warming up action interferes with the pain signal transmission through nerves.Together, they relieve neuropathic pain (pain from damaged nerves).