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Actibile 450 SR Tablet

Prescription Required

Product introduction

Actibile 450 SR Tablet is used to dissolve certain gallstones and prevent them from forming. It is also used to treat a type of liver disease called primary biliary cirrhosis. It helps break down the cholesterol that has converted into stones in your gallbladder thereby dissolving the stones.

Actibile 450 SR Tablet should be swallowed whole after a meal and with a glass of milk or water. The dose will depend on what you are being treated for and your body weight. Take it regularly to get maximum benefit and keep taking it for as long as prescribed (several months or longer). Keep taking it even if your symptoms disappear.

This medicine's most common side effects are abdominal pain, diarrhea, hair loss, itching, nausea, and rash. Not everyone gets these side effects. If you are worried about them, or they do not go away, let your doctor know.

Before taking this medicine, you should tell your doctor if you have an inflammation of the gallbladder or bile ducts, you get frequent cramp-like pain in your upper abdomen, you have been coughing up blood or you have gained weight rapidly. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor all other medicines you are taking. Women should discontinue hormonal birth control pills as they can increase the production of gallstones. During the treatment, you may need ultrasound scans, or frequent blood tests to check your liver function.

Uses of Actibile Tablet SR


How to use Actibile Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.

How Actibile Tablet SR works

Actibile 450 SR Tablet is a hepatoprotective medication. It works by reducing the amount of cholesterol in the blood and helps dissolve gallbladder stones that are composed mainly of cholesterol. It also improves liver enzymes, protects liver cells from injury caused due to toxic bile acids, and improves liver function.

Safety advice

Alcohol
There is no data available. Please consult doctor before consuming the drug.
Pregnancy
There is no data available. Please consult doctor before consuming the drug.
Breast feeding
There is no data available. Please consult doctor before consuming the drug.
Driving
There is no data available. Please consult doctor before consuming the drug.
Kidney
There is no data available. Please consult doctor before consuming the drug.
Liver
There is no data available. Please consult doctor before consuming the drug.

What if you forget to take Actibile Tablet SR?

If you miss a dose of Actibile 450 SR Tablet, skip it and continue with your normal schedule. Do not double the dose.\n

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
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Quick tips

  • Actibile 450 SR Tablet should be taken after a meal with a glass of milk or water.
  • Eat a healthy diet, exercise regularly, and avoid alcohol intake.
  • Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
  • Your doctor may monitor your liver function and bilirubin levels every month for the next 3 months after the start of therapy, and every 6 months thereafter.
  • Do not stop taking the medication without talking to your doctor.

Fact Box

Chemical Class
Bile Acids and Salts
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Action Class
Hepatoprotectives

Patient concerns

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Im pregnant with 8months and having itching in whole body. OT/PT is little higher. Tak Im taking Actibile 300. Prescribed by My doctor. Do I need to consult gastro. This is my second issue. In 1st issue I had same problem. Ans as soon as i delivered baby this all disappeared. Please suggest what to do
Dr. Dharna Gupta
Obstetrics and Gynaecology
Take actibile twice daily.use lactocalamine lotion.No need for gaatro consultYou can take tab cetrizine if itching is too muchFollow your OBS advice
Dr. Sir, I have facing depression again after 2 year , and I don't know what was it's triggered point. Kindly tell me what should i do in this situation, I am bachelor. Is Zyven is good for this situation as it was earlier suggest by psychiatrist.
Dr. Jyoti Kapoor Madan
Psychiatry
Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Reactive depression is in response to a situation like loss, sickness, trauma etc. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.
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User feedback


FAQs

When should I take Actibile 450 SR Tablet?

The suitable timing of taking this medicine might differ depending upon your condition. Your doctor might instruct you to take 2 to 3 doses per day and suggest to take the last dose at bedtime. Actibile 450 SR Tablet should be taken with water milk and can be taken with food or after food. When prescribed for dissolving gallstones, it is usually suggested to be taken once daily at night. Ideally, it should be taken at a gap of 6 hours, for example at 8 am, 2 pm and 8 pm.

Is Actibile 450 SR Tablet safe?

Actibile 450 SR Tablet is usually considered to be a safe and effective medicine. However, this medicine may have some common side effects, such as diarrhea. If diarrhea occurs, your doctor may reduce the dose and if it persists, your treatment may be discontinued. Additionally, using this medicine as a long-term therapy may also affect your liver enzyme levels. To keep a check on this, your doctor will keep monitoring your liver enzyme levels regularly. Despite these minor side effects, this medicine is supposed to be a good alternative to surgery in some patients with gallstones.

How does Actibile 450 SR Tablet help the liver?

Actibile 450 SR Tablet acts on the liver and gets concentrated in the bile secreted from the liver. This, as a result, suppresses the synthesis and secretion of cholesterol by the liver, thereby decreasing the cholesterol levels in bile. This medicine also acts by stopping the intestines from absorbing the bile salts and cholesterol. So, the reduced cholesterol saturation in the bile from the liver leads to the gradual dissolving of cholesterol from gallstones, leading to a decrease in size and their eventual dissolution. It also reduces elevated liver enzyme levels by increasing the bile flow through the liver, hence protecting the liver cells.

Does Actibile 450 SR Tablet cause weight gain?

Yes, there is a chance of weight gain with Actibile 450 SR Tablet, but it is not common. The use of Actibile 450 SR Tablet can cause weight gain when prescribed in patients with liver disease associated with chronic stasis of bile in small bile ducts of the liver. In such condition, bile cannot flow from the liver to the small intestine. Again, the chance of weight gain varies from person to person depending upon the disease, so consult your doctor if you experience weight gain.

What should I avoid while taking Actibile 450 SR Tablet?

While taking Actibile 450 SR Tablet, avoid taking an antacid preparation without consulting your doctor, as they decrease the effectiveness of Actibile 450 SR Tablet. You should also avoid medicines like cholestyramine or colestipol as they affect the effectiveness of Actibile 450 SR Tablet. So, ask your doctor about the time gap that should be maintained between Actibile 450 SR Tablet and these medicines. Also, avoid taking oral contraceptives, estrogenic hormones and blood cholesterol-lowering agents such as clofibrate as they may increase the chances of developing gallstones and act opposite to the Actibile 450 SR Tablet.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Ursodiol. Birmingham, Alabama: Axcan Pharma US, Inc.; 1997 [revised Nov. 2009]. [Accessed 25 Jan. 2019] (online) Available from:External Link
  2. Ursodiol. Bridgewater, New Jersey: Aptalis Pharma US, Inc.; 1997 [revised Jun. 2013]. [Accessed 28 Mar. 2019] (online) Available from:External Link
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Ursodiol. [Updated 2020 Jan 20]. [Accessed 20 Feb. 2020] (online) Available from:External Link
  4. Ursodeoxycholic [Package Insert]. Mumbai, India: Alkem Laboratories Ltd.; 2016. [Accessed 07 Aug. 2023]. (online) Available from:External Link
  5. The Lancet. Gastroenterology and Hepatology. [Accessed 07 Aug. 2023]. (online) Available from:External Link

Marketer details

Name: Zydus Cadila
Address: Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Country of origin: India
Expires on or after: February, 2025

A licensed vendor partner from your nearest location will deliver Actibile 450 SR Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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10.0 tablet sr in 1 strip
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