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Written By
Dr. Anuj Saini 2
MMST, MBBS
Reviewed By
Dr. Ashish Ranjan
MD (Pharmacology), MBBS
Last updated
05 Dec 2023 | 06:15 PM (IST)

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LHRH 22.5 Combipack Injection

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Product introduction

LHRH 22.5 Combipack Injection is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty).

LHRH 22.5 Combipack Injection is used to treat prostate cancer in men and to aid women in getting pregnant and treat endometriosis in women (condition where tissue that normally lines the inside of your womb (uterus) is found elsewhere)

Uses of LHRH Injection

Benefits of LHRH Injection

In Treatment of Prostate cancer

Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. LHRH 22.5 Combipack Injection decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

In Treatment of Endometriosis

Endometriosis is a condition where tissue like the lining of the womb starts to grow in other places. The main symptoms include pain in your lower stomach or back, period pain, pain during and after sex, constipation, diarrhea and feeling sick. It can also make it difficult to get pregnant. LHRH 22.5 Combipack Injection works by preventing the lining of your womb and any endometriosis tissue from growing too quickly. This will help relieve the symptoms you may have. This medicine needs to be taken regularly to be effective and you may need other medicines or procedures to help control endometriosis.

In Treatment of Uterine fibroids

Uterine fibroids are non-cancerous growths of the uterus that often appear during childbearing years. LHRH 22.5 Combipack Injection helps control the symptoms associated with uterine fibroids such as excessive menstrual bleeding, lower back pain, and also reduces the size of the existing fibroids. It blocks the action of the enzyme responsible for the growth of the broids. As a result, they decrease in size and also stop growing further.

In Treatment of Precocious puberty (premature puberty)

When puberty (change of a child’s body to adult structure and size) begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. LHRH 22.5 Combipack Injection helps delay this early onset of adulthood and limits the onset of precocious puberty. However, this medicine is given by a doctor and should not be self-administered. Follow your doctor’s instructions carefully for the most benefit.

Side effects of LHRH Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of LHRH

  • Decreased libido
  • Testicular atrophy
  • Increased sweating
  • Fatigue
  • Muscle weakness
  • Erectile dysfunction
  • Bone pain
  • Injection site reaction
  • Hot flashes

How to use LHRH Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety advice

Alcohol
CAUTION
Caution is advised when consuming alcohol with LHRH 22.5 Combipack Injection. Please consult your doctor.
Pregnancy
UNSAFE
LHRH 22.5 Combipack Injection is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of LHRH 22.5 Combipack Injection during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
LHRH 22.5 Combipack Injection may cause side effects which could affect your ability to drive.
Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with LHRH 22.5 Combipack Injection.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of LHRH 22.5 Combipack Injection in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of LHRH 22.5 Combipack Injection in patients with liver disease. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
LHRH 22.5 Combipack Injection
₹16850.0/Injection
Lupride Depot 22.5mg Injection
Sun Pharmaceutical Industries Ltd
₹17466.04/injection
4% costlier
Luprodex 22.5mg Injection
Bharat Serums & Vaccines Ltd
₹12552.85/injection
26% cheaper
Leuprosta Depot 22.5mg Injection
Alkem Laboratories Ltd
₹16812/injection
same price
Luprotas 22.5mg Injection
Intas Pharmaceuticals Ltd
₹16893.51/injection
same price
Eligard Depot 22.5mg Injection
₹22650/injection
34% costlier

Quick tips

  • LHRH 22.5 Combipack Injection helps in the treatment of locally advanced or metastatic prostate cancer.
  • It may also be used to treat endometriosis and uterine fibroids.
  • It is given as an injection either under the skin or into a muscle.
  • It may cause dizziness and visual disturbances. Don't drive or do anything that requires mental focus until you know how it affects you.
  • It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment. 
  • Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby.
  • Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.

Fact Box

Chemical Class
GNRH Analogue
Habit Forming
No
Therapeutic Class
GYNAECOLOGICAL
Action Class
GNRH agonists/analogue

Patient concerns

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Dr. Sunil Sekhri
Diabetology
During Puberty and the age range varies
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Size of penish does not increase
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Urology
Size of penis will not increase after puberty
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FAQs

Is LHRH 22.5 Combipack Injection a chemotherapy medicine?

No, LHRH 22.5 Combipack Injection is not a chemotherapy medicine. LHRH 22.5 Combipack Injection is a synthetic hormone analogue medicine which is used for the treatment of hormone-dependent conditions in men and women.

Does LHRH 22.5 Combipack Injection stop periods?

Yes, the periods tend to stop while taking LHRH 22.5 Combipack Injection injections as this medicine alters the reproductive hormones in females. Sometimes, there can be vaginal bleeding in few cases. If this occurs, please contact your doctor to get yourself assessed and follow the direction of your doctor.

Is LHRH 22.5 Combipack Injection a hormonal medicine and can it be given in pregnancy?

Yes, LHRH 22.5 Combipack Injection is a hormonal medicine which alters the reproductive hormones when given in females. This medication is not recommended for use in women who are or may become pregnant because this can harm the fetus in the womb. Using this medicine during pregnancy may also lead to abortion of the baby. Do inform your doctor if you are pregnant or are planning to get pregnant before starting this medication.

Can taking LHRH 22.5 Combipack Injection affect my bones?

Yes, there are chances of LHRH 22.5 Combipack Injection affecting your bones. Using LHRH 22.5 Combipack Injection may cause a decrease in bone mineral density and make the bones weaker. In women, bone density should be assessed before starting the treatment. Special care and monitoring should be done in women with increased risk of osteoporosis. If at all needed, additional medicines may be given to prevent the development of osteoporosis in patients with decreased bone mineral density.

Can LHRH 22.5 Combipack Injection cause diabetes or increased blood sugar?

Yes, LHRH 22.5 Combipack Injection may cause an increase in blood sugar levels, worsening the blood glucose control in patients with diabetes. It can even increase the risk of developing diabetes. Therefore, you must monitor the blood glucose and/or glycosylated hemoglobin (HbA1c) from time to time to keep a track of the glucose control and inform your doctor in case you develop any problem. Diabetic patients when prescribed this medication should monitor the sugar levels more frequently while taking this treatment.
Related lab tests
  • Prostate Specific Antigen (Free) PSA
  • Prostate Specific Antigen (Total) PSA

    • Related ayurvedic ingredients

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    Disclaimer:

    Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

    References

    1. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 959.
    2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 787-88.
    3. Leuprorelin acetate. Wooburn Green, High Wycombe: Takeda UK Ltd.; 2011 [revised 11 Jun. 2018]. [Accessed 25 Jan. 2019] (online) Available from:External Link
    4. Leuprolide Leuprorelin acetate. Fort Collins: TOLMAR Inc.; 2002 [revised Feb. 2016]. [Accessed 26 Mar. 2019] (online) Available from:External Link

    Marketer details

    Name: Medrhans Pharmaceuticals Private Limited
    Address: Plotno:91,Road No:4,Second Floor Himapuri Colony,Mansoorabad,Lb Nagar Hyderabad Hyderabad Tg 500068 India
    Country of origin: India
    Expires on or after: February, 2025

    A licensed vendor partner from your nearest location will deliver LHRH 22.5 Combipack Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

    In case of any issues, contact us

    Email ID: [email protected]
    Phone Number: 0124-4166666
    Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
    ₹16470₹16850Get 2% OFF
    ₹15678+ free shipping withCare Plan Logo
    Inclusive of all taxes
    Get this discount by applying coupon 1MGALL on the cart. Max. coupon discount is ₹380. T&C apply.
    1 Box
    1.0 Injection in 1 box
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