Livonibe 200mg Tablet belongs to the class of medicines known as tyrosine kinase inhibitors used in the treatment of liver cancer, kidney cancer, and thyroid cancer.

Livonibe 200mg Tablet is used to treat different types of cancer

Uses of Livonibe Tablet

Benefits of Livonibe Tablet

In Liver cancer

Liver cancer is the cancer that develops in the cells of the liver called hepatocytes. There may be no symptoms present in the early stages of the cancer but as the disease advances to later stages symptoms such as weight loss, stomach pain, vomiting and yellowed skin. Livonibe 200mg Tablet kills the cancer cells and prevents further growth and spread of cancer to other unaffected areas. Follow your doctor’s instructions carefully and do not drink alcohol or smoke. Alcohol intake or smoking can worsen your condition and hinder your recovery.

In Kidney cancer

Livonibe 200mg Tablet is used to treat kidney cancer and its associated symptoms such as blood in the urine, unexplained low back pain or weight loss, fatigue, loss of appetite, etc. It stops cancer growth and prevents multiplication of cancer cells. This restricts the advancement of cancer to other unaffected regions. You need to follow your doctor’s instructions very carefully to recover.

In Thyroid cancer

Thyroid is a butterfly-shaped gland located at the base of your neck. Your thyroid produces hormones that regulate your heart rate, blood pressure, body temperature and weight. Thyroid cancer occurs in the cells of the thyroid and it might not cause any symptoms at first. Livonibe 200mg Tablet restricts the oxygen supply of the cancer cells and stops its growth as well as further spread. It is a potent and very toxic medicine and you should discuss the risks and benefits with your doctor. You should avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.

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Side effects of Livonibe Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Livonibe

Fatigue
Nausea
Loss of appetite
Diarrhea
Abdominal pain
Hair loss
Weight loss
Rash
Painful blisters on hands and feet

How to use Livonibe Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Livonibe 200mg Tablet is to be taken empty stomach.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Livonibe 200mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Livonibe 200mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

UNSAFE

Livonibe 200mg Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

SAFE

Livonibe 200mg Tablet does not usually affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Livonibe 200mg Tablet is safe to use in patients with kidney disease. No dose adjustment of Livonibe 200mg Tablet is recommended.
Regular monitoring of blood tests may be advised while you are taking this medicine.

Liver

CAUTION

Livonibe 200mg Tablet should be used with caution in patients with severe liver disease. Dose adjustment of Livonibe 200mg Tablet may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Livonibe 200mg Tablet

₹106.7/Tablet

Sorafenat 200mg Tablet

Natco Pharma Ltd

₹74/tablet

31% cheaper

Soranib Tablet

Cipla Ltd

₹68.97/tablet

35% cheaper

Nexavar 200mg Tablet

Bayer Zydus Pharma Pvt Ltd

₹2433.96/tablet

2181% costlier

Sonora 200mg Tablet

Intas Pharmaceuticals Ltd

₹4.25/tablet

96% cheaper

Soranib Tablet

Cipla Ltd

₹75.87/tablet

29% cheaper

View all substitutes

Quick tips

Livonibe 200mg Tablet is used in the treatment of liver, kidney, and thyroid cancer.
Take it without food, or with a low fat meal and a full glass of water.
Take it at the same time everyday to maintain consistent levels in your body.
Women who could get pregnant should use a reliable method of contraception to prevent pregnancy while taking this medicine.
Your doctor may regularly monitor your blood pressure while you are taking this medicine.
Inform your doctor if you get a skin rash, or any pain, swelling, and redness of your hands and feet while you are taking this medicine.
Do not change the dose or discontinue use without consulting your doctor.

Fact Box

Chemical Class

Diarylethers Derivative

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Tyrosine kinase inhibitors

Patient concerns

Hello sir, Plz help me to find out whether im really having thyroid cancer or not. I have taken two consultation from different doctors, one is saying she got hypothyroid or something, and she is taking medicines from that doctor, it's been 3months i guess now.( Homeopathy) another doctor saying negative, like she has no problem at all, We dont know what to, we should continue taking medicines or not Plz help me out asap. Thank you

Dr. Vijay Verma

ENT

there is no cancereven thyroid level is normal

How we can find out parient is CA and which report we can do for know the patient is CA

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Thr is no single test for cancerWhich cancer ur looking for

Smears show metastatic mucinous adenocarcinoma.HISTOPATHOLOGY REPORT.sir is there any treatment Sir my mom firstly suffered from stomach pain.Then say about doing ultra sound test which is as:Neoplasm Stomach Pylrus.Fresh blood in corpus .polypoid growth in pylrus biopy taken from HPE Sir please help doctors already said there is no treatment for this stomach cancer disease

Dr. Sanjay Singh Rai

Medical Oncology and Hematology

Cancer is treated based on stage of cancerPlease upload reports of Ultrasound and endoscopy

FAQs

How is Livonibe 200mg Tablet administered?

Livonibe 200mg Tablet is an oral medicine and you should take it exactly as per your doctor’s advice. It can be taken without food or with low to moderate fat meal. It should not be taken with high-fat meal which will make Livonibe 200mg Tablet less effective. If you are taking high-fat meal, take Sorafenib 1 hour before or two hours after high-fat meal.

For how long do I need to take Livonibe 200mg Tablet?

If Livonibe 200mg Tablet suits you well, then you should continue taking it for the duration suggested by the doctor. However, if you experience any side effect that bothers you, talk to your doctor immediately.

Do I need to take a treatment along with Livonibe 200mg Tablet for it to work?

Livonibe 200mg Tablet is used as a monotherapy, that is, it is a medicine which is used alone rather than in combination with other treatments like radiotherapy or chemotherapy.

How do I know if I am responding to Livonibe 200mg Tablet?

While receiving treatment with Livonibe 200mg Tablet, your doctor will most likely recommend regular scans to monitor the size of the tumor. You may also need to get regular blood tests to see if the deranged liver or kidney functions have improved or not.

What are the serious side effects that can occur while taking Livonibe 200mg Tablet?

The possible serious side effects that may occur (not in everyone) include heart attack and heart failure, increased risk of bleeding, high blood pressure, skin problems and wound healing problems. Some other side effects which get highlighted when you go through various tests are decreased blood flow to the heart, swelling of the liver, an opening in the wall of stomach or intestines (perforation), changes in electrical activity of the heart (QT prolongation) and changes in thyroid hormone levels.

Does Livonibe 200mg Tablet affect blood sugar levels?

Yes, Livonibe 200mg Tablet can cause a decrease in the blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, it is important that the patients having diabetes check their blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted.

I have developed redness and pain in my palms and soles ever since I started using Livonibe 200mg Tablet. My skin is also coming off. Is this dangerous? What should I do?

It seems you have developed hand and foot skin reaction due to Livonibe 200mg Tablet. Consult your doctor who will either interrupt your therapy for sometime or change your dose. He might also suggest some cream or lotion to treat the problem. If the problem is severe, consult a skin doctor.

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Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

Complete Blood Count

Thyroid Profile Free

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1740.
Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1274-75.
Sorafenib. Emeryville, California: Onyx Pharmaceuticals, Inc.; 2005 [revised Oct. 2010]. [Accessed 24 Jan. 2019] (online) Available from:
Sorafenib tosilate. Reading, Berkshire: Bayer Plc.; 2006 [revised Jun. 2018]. [Accessed 27 Mar. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:

Marketer details

Name: BDR Pharmaceuticals Internationals Pvt

Address: 407-408, Sharda Chambers, New Marine Lines, Mumbai 400 020 (Maharashtra), New Marine Lines, Marine Lines, Mumbai, Maharashtra 400020

Country of origin: India

The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.