Medcovorin Injection is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used to treat overdose of methotrexate.

Medcovorin Injection is used to protect the body cells against the harmful effects of anti-cancer medicines during treatment

Uses of Medcovorin Injection

Prevention of Harmful effects of methotrexate

Benefits of Medcovorin Injection

In Prevention of Harmful effects of methotrexate

Medcovorin Injection helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Medcovorin Injection will prevent the other side effects such as anemia.

Side effects of Medcovorin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Medcovorin

Injection site reactions (pain, swelling, redness)

How to use Medcovorin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Medcovorin Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Medcovorin Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Medcovorin Injection during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Medcovorin Injection does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Medcovorin Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Medcovorin Injection in patients with liver disease. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Medcovorin Injection

₹127/Injection

Leevarin 50 Injection

Admac Pharma Ltd

₹299/injection

18% costlier

Quick tips

You have been prescribed Medcovorin Injection to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Medcovorin Injection may counteract the antiepileptic effects.

Fact Box

Chemical Class

Glutamic acid Derivatives

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Cytoprotective agents- methotrexate

Patient concerns

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Sexology

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Best psoriasis health medicine

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Dermatology

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FAQs

What is Medcovorin Injection used for?

Medcovorin Injection is used to prevent harmful effects of methotrexate (cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Medcovorin Injection is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency. How long does it take for Medcovorin Injection to work?

How long does it take for Medcovorin Injection to work?

Medcovorin Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Medcovorin Injection?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Medcovorin Injection. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Medcovorin Injection contains calcium.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Medcovorin Injection?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Calcium folinate. Hurley, Maidenhead: Hospira UK Ltd.; 2003 [revised Jan. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
Levoleucovorin. Parsippany, New Jersey: Actavis Pharma; 1952 [revised Sep. 2016]. [Accessed 26 Mar. 2019](online) Available from:

Marketer details

Name: Medi Biotech Pvt Ltd

Address: Medi Biotech Private Limited, No. 28, Subbu Street , L.B. Road Tiruvanmiyur, Thiruvanmiyur, Chennai-600041, Tamil Nadu, India

Country of origin: India

₹127

Inclusive of all taxes

MRP₹253 50% OFF

5.0 ml in 1 vial

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Medcovorin Injection

Product introduction

Uses of Medcovorin Injection

Benefits of Medcovorin Injection

In Prevention of Harmful effects of methotrexate

Side effects of Medcovorin Injection

Common side effects of Medcovorin

How to use Medcovorin Injection

Safety advice

All substitutes

Quick tips

Fact Box

Patient concerns

FAQs

What is Medcovorin Injection used for?

What is megaloblastic anemia?

How long does it take for Medcovorin Injection to work?

What are some of the laboratory tests conducted before or during the treatment with Medcovorin Injection?

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Medcovorin Injection?

Want to share the information?

Disclaimer:

References

Marketer details

Lab tests offered by us