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Phenytoin Sodium 100mg Injection

Prescription Required

Product introduction

Phenytoin Sodium 100mg Injection is used to treat and prevent epilepsy (seizures). It controls seizures by decreasing the abnormal and excessive activity of the nerve cells in the brain. It is given when this medicine cannot be given orally, such as in hospitalized patients.

Phenytoin Sodium 100mg Injection is given under the supervision of a healthcare professional and should not be self-administered. It is advisable to take it at the same time each day as this helps to maintain a constant level of medicine in the body. If you have missed a dose, take it as soon as you remember it. You should finish the full course of treatment even if you feel better as stopping the medication without talking to your doctor may cause non-stop seizures (called status epilepticus), which can be life-threatening.

The most common side effects of this medicine include skin rashes, headache, feeling or being sick, difficulty sleeping, dizziness, and feeling sleepy or drowsy. Additionally, you may notice some injection site reactions like redness or swelling. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.

Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression, or suicidal thoughts. Also let your healthcare team know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.

Uses of Phenytoin Sodium Injection

Benefits of Phenytoin Sodium Injection

In Treatment and prevention of Epilepsy/Seizures

Phenytoin Sodium 100mg Injection is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

Side effects of Phenytoin Sodium Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Phenytoin Sodium

  • Rash
  • Headache
  • Dizziness
  • Vomiting
  • Nausea1a
  • Slurred speech
  • Vertigo
  • Confusion
  • Nervousness
  • Constipation
  • Tremor
  • Altered walking

How to use Phenytoin Sodium Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Phenytoin Sodium Injection works

Phenytoin Sodium 100mg Injection is an antiepileptic medication. It controls seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

Safety advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Phenytoin Sodium 100mg Injection.
Pregnancy
CONSULT YOUR DOCTOR
Phenytoin Sodium 100mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
SAFE IF PRESCRIBED
Phenytoin Sodium 100mg Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Please consult your doctor.
Driving
UNSAFE
Phenytoin Sodium 100mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Phenytoin Sodium 100mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Phenytoin Sodium 100mg Injection may be needed. Please consult your doctor.
Liver
CAUTION
Phenytoin Sodium 100mg Injection should be used with caution in patients with liver disease. Dose adjustment of Phenytoin Sodium 100mg Injection may be needed. Please consult your doctor.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Phenytoin Sodium 100mg Injection
₹37.5/Injection
Epiwin 100mg Injection
Ikon Remedies Pvt Ltd
₹11.61/injection
85% cheaper
Epilet 100mg Injection
Innovative Pharmaceuticals
₹11.61/injection
85% cheaper
Fensant 100mg Injection
SBS Biotech Limited
₹10.9/injection
85% cheaper

Quick tips

  • Take your medication regularly as directed by your doctor as missing doses can trigger seizures.
  • Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you.
  • Some healthy tips to prevent seizures:
    • Practice yoga every day.
    • Get enough sleep at nighttime.
    • Limit the use of screen time such as mobile/laptop.
    • Take your medication on time.
  • It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you.
  • It may increase blood sugar levels. Inform your doctor if you are taking any medicines to treat diabetes.
  • It may cause swollen gum (gum hypertrophy), hence take care of oral or dental hygiene.
  • Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts.
  • Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Fact Box

Chemical Class
Hydantoin Derivative
Habit Forming
No
Therapeutic Class
NEURO CNS
Action Class
Sodium channel modulators (AED)

Patient concerns

arrow
My said uncle is taking Epilan 100mg for epileptic reason. But this medicine is not easily available at his place. Can he take Epicom 100mg as its substitute? Please reply. Or any other available substitute?
Dr. Ravindra Srivastava
Neuro Surgery
TAB. EPTOIN / TAB. CELETOIN/ TAB. PHENYTOIN.
Is there any toxic effect for the drug garoin(phenobarbitone and phenytoin) in constipation child If the child doesnot having epilepsy also??
Dr. Gopal Samdani
Paediatrics
Toxicity is dose dependent
arrow

FAQs

For how long does Phenytoin Sodium 100mg Injection stay in your system?

On an average, Phenytoin Sodium 100mg Injection may stay in your system for 5-6 days. This duration varies from person to person. In some cases, it may stay for about 9-10 days.

Who should avoid taking Phenytoin Sodium 100mg Injection?

You should not take Phenytoin Sodium 100mg Injection if you have liver disease, especially if you have a history of developing a liver problem due to Phenytoin Sodium 100mg Injection. Also, patients taking Delavirdine (a medicine used in the treatment of HIV infection) should not take Phenytoin Sodium 100mg Injection. Phenytoin Sodium 100mg Injection may reduce the effectiveness of Delavirdine on HIV and the virus may also become resistant to Delavirdine. It is advised that you inform your doctor if you have any existing heart disorder before you receive Phenytoin Sodium 100mg Injection.

Can I take Phenytoin Sodium 100mg Injection with ibuprofen?

Phenytoin Sodium 100mg Injection can be taken with ibuprofen. No drug-drug interactions have been reported between the two. However, interactions can occur. Please consult your doctor before taking the two medicines together.

What are the effects of Phenytoin Sodium 100mg Injection on children?

The most common side effects related to Phenytoin Sodium 100mg Injection in children are jerky movements of the eyes (nystagmus) and overgrowth of the gums. In some children, Phenytoin Sodium 100mg Injection causes problems with thinking or behavior, mood change, slow or clumsy movements, or a loss of energy. Other side effects from high doses include unsteadiness in the feet and hands, sleepiness, and vomiting. These may be avoidable if the dose is increased slowly. These side effects quickly disappear when the dose is reduced.

Does Phenytoin Sodium 100mg Injection cause weight gain?

Phenytoin Sodium 100mg Injection has not been reported to cause weight gain. However, weight loss can occur with longer term use of a higher dose of Phenytoin Sodium 100mg Injection. Please consult your doctor if you experience weight gain after taking Phenytoin Sodium 100mg Injection.

Does Phenytoin Sodium 100mg Injection make you sleepy?

Phenytoin Sodium 100mg Injection can make you feel sleepy (sedation, somnolence, and drowsiness). Please consult your doctor if you feel very sleepy after taking Phenytoin Sodium 100mg Injection, especially during the first few weeks of treatment or following a dose increase. Talk to your doctor as you may be advised not to drive or use machines until it is established that your ability to perform such activities is not affected.

Does Phenytoin Sodium 100mg Injection affect birth control?

Phenytoin Sodium 100mg Injection does affect birth control. Phenytoin Sodium 100mg Injection can decrease the effect of oral contraceptives (birth control pills) which can make the contraceptive (birth control) effect unreliable. Please talk to your doctor if you are asked to take the two medicines together as you may need to use extra protection for birth control.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 591-93.
  2. Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 403-405.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1111-116.
  4. Drugs.com. Phenytoin. [Accessed 22 Mar. 2019] (online) Available from:External Link
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198. [Accessed 22 Mar. 2019] (online) Available from:External Link
  6. Phenytoin. Hurley, Maidenhead: Hospira UK Ltd.; 1995 [revised Aug. 2017]. [Accessed 22 Mar. 2019] (online) Available from:External Link
Country of origin: India
Expires on or after: February, 2025

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Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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